Notch is known to be an important protein in development, maintaining undifferentiated proliferating cells.The gene responsible for manufacturing Notch protein is often damaged or mutated in patients with a form of blood cancer known as T-cell acute lymphoblastic leukaemia (ALL) leading to constitutive Notch activation and uncontrolled cell proliferation. Scientists have developed a technique to disrupt Notch's function and, when tested in mice, this technique has shown to limit the growth of cancer cells.
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